Advanced Biomedical Optical Imaging Laboratory, National Taiwan University
About
The ABOIL research group at NTU focuses on the development and exploration of
non-invasive
three-dimensional (3D) optical imaging techniques for biomedical applications.
In recent years, we have also extended these technologies to industrial
inspection, such as defect detection in
(opto)electronic semiconductor chips, wafers, and packaging.
Our research team covers a wide range of topics, including optics
and optomechanical design,
development of
high-performance imaging acquisition/processing engine,
graphical user
interface design, machine vision image pro
cessing and feature enhancement
, high-frequency signal analysis, image feature extraction based on machine lear
ning or artificial intelligence, embedded processor development, and the
development of heterogeneous computing architectures
based on edge computing and AI modules
International collaborators:
Prof. Yoshiaki Yasuno, Computational Optics Group, University of Tsukuba, Japan.
Prof. Bernhard Baumann, Medical University of Innsbr
uck/Medical University of Vienna
(Adjunct), Austria.
Prof. Martin Villiger, Wellman Center for Photomedicine/Harvard Medical School, USA.
Prof. Gijs von Soest, Department of Cardiology, Erasmus Medical Center, Netherlands.
Dr. Karol Karnowski, Intern
ational Centre for Translational Eye Research (ICTER), Polish
Academy of Science, Poland
Industrial collaborators:
Dr. Cheng-Kuang Lee, NVIDIA AI Technology Center
Dr. Jyh-Tsung Hsieh,
Bandwidth10
Ltd.
Principal Investigator
Prof. Hsiang-Chieh Lee 李翔傑
Autobiography:
Dr. Hsiang-Chieh Lee
is currently an Associate Professor at the Graduate Institute of Photonics and
Optoelectronics (GIPO) and the Department of Electrical Engineering at National Taiwan University
(NTU).
He received his Bachelor's and Master's degrees in Civil Engineering and Electro-Optical Engineering
from NTU in 2004 and 2006, respectively. He then pursued a Ph.D. in Electrical Engineering at the
Department of Electrical Engineering and Computer Science (EECS) at the Massachusetts Institute of
Technology
(MIT), focusing on the bioelectronics division, and obtained his doctorate in 2017. Dr. Lee joined
NTU as an Assistant
Professor in February 2017 and founded the Advanced Biomedical Optical Imaging Laboratory (ABOIL)at
GIPO.
Dr. Lee is a member of the Phi Tau Phi Scholastic Honor Society of the Republic of China (R.O.C.)
and a
recipient of both the Young Scholar Fellowship Program and the Career Development Grant awarded by
the
Ministry of Science and Technology (MOST, now the National Science and Technology Council, NSTC)
and
the National Health Research Institutes (NHRI) in Taiwan, respectively. In 2023, he was also honored
with the NSTC Ta-You Wu Memorial Award
in recognition of his contributions to the field of optics and photonics.
Dr. Lee's current research interests include the development of optical coherence tomography (OCT)
and
functional OCT imaging technologies for a variety of biomedical applications, such as endoscopy,
dentistry,
dermatology, oncology, and ophthalmology. In collaboration with the laser industry,
he is also working on
the development of novel laser light sources for OCT and nondestructive inspection or testing
applications.
In addition, Dr. Lee has been developing machine learning and artificial intelligence
(AI)-based image processing algorithms
for biomedical and industrial nondestructive inspection. Recently, his group has
focused on creating low-cost yet intelligent imaging instruments that leverage edge computing and
heterogeneous computation frameworks.
Dr. Lee has delivered invited talks at
various international conferences, including SPIE BISC and OPIC ALPS in
Japan. He also serves as a member of the Technical Program Committee (TPC) for SPIE BISC, OPIC
ALPS,
and OPTICA/SPIE ECBO conferences.
Research
High-speed optical tomographic imaging technology for industrial
applications
Traditional time-domain and spectral-domain OCT systems commonly
employ galvanometric scanners (Galvos) for point-by-point scanning. While effective,
Galvos introduce mechanical complexity, sinusoidal waveform distortion, and motion
jitter, all of which limit imaging speed and compromise system stability. To overcome
these challenges, line-field OCT (LF-OCT) has emerged as a powerful alternative. LF-OCT
utilizes line-shaped illumination in combination with an area-array detector to capture
an entire B-scan image within a single camera exposure. This design eliminates the need
for mechanical beam scanning across the sample surface during B-scan acquisition,
significantly improving image acquisition speed and robustness against motion artifacts.
As a result, LF-OCT is particularly well-suited for high-throughput or real-time
non-destructive inspection applications.
High-power femtosecond (fs) laser processing has become a powerful
tool for material modification, enabling micromachining and functionalization at micro-
to nanoscale precision. However, evaluating laser-induced effects within biological or
industrial samples remains challenging—conventional inspection techniques are often
destructive or lack sufficient resolution to capture subtle internal structural changes.
To address this limitation, we aim to develop a multimodal system that integrates
femtosecond laser ablation/machining with an optical coherence tomography (OCT) platform
for real-time, non-invasive evaluation. This approach enables simultaneous processing
and imaging, facilitating precise monitoring of laser–material interactions and
structural evolution during fabrication or treatment.
Novel optical tomographic technologies for next-generation digital
dentistry applications
Optical coherence tomography (OCT) enables high-resolution,
non-invasive imaging of dental tissues; however, its clinical adoption is limited by
imaging artifacts such as shadowing and refractive distortions. To address these
challenges, we have developed a pipeline image-fusion algorithm that integrates
refractive distortion correction with a multi-view registration framework, combining
surface contour extraction and Iterative Closest Point (ICP)-based alignment. This
approach effectively restores geometric accuracy, enhances visualization of internal
tooth structures, and reduces misalignment artifacts. In parallel, we have developed a
novel OCT imaging system capable of simultaneous image acquisition from three distinct
viewing angles within a single scan, eliminating the need for mechanical sample
repositioning.
Capturing subgingival finish lines remains a major challenge in
digital dentistry, as intraoral scanners often lack sufficient accuracy, compromising
the precision of restoration margins. While OCT provides high-resolution, non-invasive
imaging, its performance can be degraded by scattering and refractive index variations.
To overcome these limitations, we introduce a novel OCT-based method that combines
refractive index compensation with an automated Fourier transform–based registration and
stitching algorithm. This technique enables accurate alignment and fusion of multiple
volumetric OCT datasets into complete 3D reconstructions of dental structures. As a
result, it enhances the visualization of subgingival finish lines and offers a promising
alternative to conventional intraoral scanners in clinical dentistry.
Novel wavelength-swept lasers for retinal and full-eye imaging
Swept-source OCT (SS-OCT), which employs a wavelength-swept light
source, enables high-speed, non-invasive, 3D imaging of both the anterior and posterior
segments of the human eye. However, the widespread adoption of SS-OCT remains limited by
the high cost of the swept source, which significantly contributes to the overall system
expense, thereby restricting accessibility in local clinics and under-resourced regions.
To address this challenge, we investigate feasibility of HCG-VCSEL as a compact and
cost-effective alternative light source for OCT imaging. In this study, we have
developed multiple HCG-VCSEL-based SS-OCT systems operating at ~1060 nm to validate its
comprehensive imaging capabilities, including retinal and full-eye imaging, long-range
centimeter-scale imaging, and polarization-sensitive OCT (PS-OCT) for birefringent
tissue characterization.
Accurate ocular biometry is critical for investigating refractive
errors and developmental eye conditions in both humans and animal models. Among these,
mice have become particularly valuable due to the availability of genetically defined
strains with well-characterized genomes. Despite their small eye size, murine eyes share
key anatomical and structural features with human eyes, making them an excellent model
for translational ocular research. In this study, we developed an accurate and stable
protocol for in vivo measurement of axial length in mice, addressing challenges arising
from their unpredictable visual fixation. By leveraging a high-speed, high-resolution,
extended-depth OCT system, we achieved precise and repeatable axial length measurements
from a single cross-sectional image.
Portable optical imaging platform based on an embedded system
OCT provides non-invasive, high-resolution imaging of biological
tissues and is widely used in ophthalmology and dermatology for early diagnosis and
treatment monitoring. However, conventional OCT systems remain costly and bulky,
limiting accessibility in resource-constrained settings. Although portable
implementations leveraging single-board computers or GPU-based platforms have been
explored, their limited processing power and resource competition between image
reconstruction and AI workloads constrain clinical utility. To address these challenges,
we have developed a compact spectral-domain OCT (SD-OCT) system that integrates
FPGA-based real-time signal reconstruction with an NVIDIA Jetson platform dedicated to
graphical user interface (GUI) control and AI-driven analytics. This heterogeneous
architecture reduces both system cost and physical footprint, while enabling
intelligent, portable OCT solutions suitable for broader deployment in point-of-care and
telemedicine applications.
Label-free volumetric imaging of the 3D cell cultures
Cancer remains one of the leading causes of death worldwide,
underscoring the importance of accurately assessing treatment effectiveness. Tumor-cell
spheroid models have emerged as a well-established tool for drug discovery and
therapeutic screening, offering physiologically relevant insights into tumor
microenvironments. However, traditional imaging techniques, such as bright-field and
phase-contrast microscopy, are limited to 2D visualization of thin tissue sections or
cell cultures and often require staining or fluorescent labeling. In this study, we
developed a novel spectral-domain optical coherence microscopy (SD-OCM) system that
incorporates custom-designed beam scanning protocols and dynamic imaging analysis
algorithms. This dynamic OCM imaging approach enables label-free, three-dimensional
visualization of the architectural and functional dynamics of tumor-cell spheroids,
providing a powerful tool for non-invasive, longitudinal monitoring of cancer treatment
response.
Machine learning/AI-based imaging algorithm development
OCT and OCT angiography (OCTA) are indispensable retinal imaging
modalities that provide detailed insights into both structural morphology and vascular
networks, making them essential tools for the diagnosis and management of ophthalmic
diseases. Despite their clinical value, conventional diagnostic approaches remain
time-consuming and heavily reliant on expert interpretation, which introduces
inter-observer variability and limits the scalability of large-scale screening programs.
In this study, we propose an AI-based diagnostic framework that integrates complementary
structural and vascular features extracted from OCT and OCTA to automatically classify
myopic choroidal neovascularization (mCNV) into active and inactive stages. This
approach not only enhances diagnostic accuracy but also demonstrates strong potential
for clinical translation, paving the way for automated, objective, and scalable
ophthalmic screening systems.
In this study, we aim to develop a terminal defect inspection
system optimized for industrial manufacturing environments. Two key design strategies
are introduced: (1) A coarse-to-fine bounding box annotation method that reduces the
cost of manual labeling and enables the training of object detection models even when
only classification datasets are available; and (2) An API-based wireless edge computing
framework, where inference is performed on a dedicated edge device, and results are
transmitted via network communication. This architecture enables stable, low-latency
inspection and embeds the deep learning model within a self-contained edge device,
addressing practical challenges of deploying and maintaining intelligent inspection
systems in real-world production line environments.
Publications
Patents
K. Liang, J. G. Fujimoto, H. Mashimo , O. O. Ahsen, H. C. Lee , M. G. Giacomelli , Z. Wang:
Scanning optical probe. Massachusetts Institute of Technology, Dec. 2023: US 11 , 835 , 707 B2
H. - C. Lee , T. - H. Chen, T. - Y. Tsai, C. - B. Chueh, Y. - W. Chang, C. - Y., Wang : Signal
control module and low coherence interferometry . National Taiwan University, Nov. 2022 : US
11,496,677 B2.
C. - H. Chiang , T. - Y . Li , M. - L . Tsai , Y . - J . Lee , H. - C. Lee : Method for
synthesizing perovskite quantum dot film . National Taiwan University of Science and Technology,
December 2021: US 11 , 193 , 060 B2
M. T. Tsai, H. C. Lee , C. K. Lee, Y. M. Wang, C. P. Chiang, H. M. Chen, C. C. Yang: Method for
analyzing mucosa samples with optical coherence tomography . National Taiwan University,
September 2011: US 8 , 023 , 119
蔡孟燦 、 李翔傑 、 李正匡 、 王義閔 、 江俊斌 、 陳信銘 、 楊志忠 , “ 以光學同調斷層掃瞄分析黏膜 樣本的方法 ( Method for analyzing a mucosa
sample with optical coherence tomography ),” 中 華 民 國專利第 I359007 號 , Mar. 2012
Book Chapters
M.-S. Wu, Y.-C. Wu, and H.-C. Lee, Optical Coherence Tomography (OCT): Clinical Applications
of Endoscopic Catheter in Gynecology, Instrument Today, 224, pp. 21 - 27, 2020
A. D. Aguirre, C. Zhou, H.-C. Lee, O. O. Ahsen, and J. G. Fujimoto, Optical Coherence
Microscopy, in Optical Coherence Tomography: Technology and Applications, 2nd Ed., J.G. Fujimoto
and W. Drexler, Eds., Springer-Verlag, Berlin, Heidelberg, 2015.
Y. -C. Wu, H. -C. Lee, Y. -T. Ju, S. -C. Huang and C. -W. Chen, "Enabling Robotic
Tele-Microsurgery: High-Resolution RGB-D Streaming Based on Swept Source OCT and Data-Driven
Galvanometer Control," in IEEE/ASME Transactions on Mechatronics, early access (2025).
M. Varaka, C. W. Merkle, L. May, S. Worm, M. Augustin, F. Fanjul-Vélez, H.-C. Lee, A. Wöhrer,
M. Glösmann, and B. Baumann, “Polarization-insensitive optical coherence tomography using
pseudo-depolarized reference light for mitigating birefringence-related image artifacts,”
Journal of Biomedical Optics, 11, 116001 (2024).
T.-A. Wang, N. H. Trung, H.-C. Lee, C.-K. Lee, M.-T. Tsai, and Y.-L. Wang, “Quantitative
Evaluation of Caries and Calculus with Ultrahigh-Resolution Optical Coherence Tomography,”
Bioengineering, 10, 1317 (2023).
B.-Y. Lee, C.-H. Cheng, C.-T. Tsai, H.-S. Lin, S.-C. Kao, P. Chiang, H.-C. Lee, T.-T. Shih,
H.-C. Kuo, and G.-R. Lin, “Si Mach-Zehnder Modulator for PAM-4, QAM-OFDM, and DMT Transmission
at
C-Band,” IEEE Journal of Selected Topics in Quantum Electronics, 29, 350012 (2023).
Y.-W. Lo, A. Y.-L. Lee, Y.-C. Liu, H.-H. Ko, H.-H. Peng, H.-C. Lee, P.-Y. Pan, C.-H. Chiang, and
S.-J. Cheng, “β-glucan therapy converts the inhibition of myeloid-derived suppressor cells in
oral cancer patients,” Oral Diseases, 28, 1484 (2022).
Y. Luo, M. L. Tseng, S. Vyas, H. Y. Kuo, C. H. Chu, M. K. Chen, H.-C. Lee, W.-P. Chen, V. Su, X.
Shi, H. Misawa, D. P. Tsai, and P.-C. Yang, “Metasurface based abrupt autofocusing beam for
biomedical applications,” Small Methods, 6, 2101228 (2022).
C. Y. Ng, T.-A. Wang, H.-C. Lee, B.-H. Huang, and M.-T. Tsai, “In Vivo Identification of Skin
Photodamage Induced by Fractional CO2 and Picosecond Nd:YAG Lasers with Optical Coherence
Tomography,” Diagnostics,12, 822 (2022).
M.-T Tsai, W.-J. Chen, T.-Y. Tsai, H.-C. Lee*, C.-C. Wang, and Y.-J. Lee, “Optical coherence
tomography/angiography-guided tumor ablation with a continuous-wave laser diode,” IEEE Access,
8,
43191-43199 (2020). (*Corresponding author)
H.-H Peng, H.-H. Kuo, N.-C. Chi, Y.-P. Wang, H.-C. Lee, P.-Y. Pan, M.Y.-P. Kuo and S.-J. Cheng,
“Upregulated NPM1 is an independent biomarker to predict progression and prognosis of oral
squamous cell carcinomas in Taiwan,” Head & Neck, 42, 5-13 (2020).
M.-T Tsai, Y.-L. Wang, T.-W. Yeh, H.-C. Lee, W.-J. Chen, J-L. Ke and Y.-J. Lee, “Early detection
of enamel demineralization by optical coherence tomography,” Sci. Report, 9, 17154 (2019).
A. Abramson, E. Caffarel-Salvador, V. Soares, D. Minahan, R. Y. Tian, X. Lu, D. Dellal, Y. Gao,
S. Kim, J. Wainer, J. Collins, S. Tamang, A. Hayward, T. Yoshitake, H.-C. Lee, J. Fujimoto, J.
Fels, M.R. Frederiksen, U. Rahbek, N. Roxhed, R. Langer and G. Traverso, “A luminal unfolding
microneedle injector for oral delivery of macromolecules,” Nature Medicine, 25, 1512–1518
(2019).
T.-A Wang, M.-C. Chan, H.-C. Lee, C.-Y. Lee and M.-T. Tsai, “Ultrahigh-resolution optical
coherence tomography/angiography with an economic and compact supercontinuum laser,” Biomed.
Opt.
Express, 11, 5687-5702 (2019).
O.O. Ahsen, K. Liang, H.-C. Lee, M.G. Giacomelli, Z. Wang, B. Potsaid, M. Figueiredo, Q. Huang,
V. Jayaraman, J.G. Fujimoto, and H. Mashimo, “Assesment of Barrett's esophagus and dysplasia
with
ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography,” Endoscopy,
51, 355-39 (2019).
O.O. Ahsen, K. Liang, H.-C. Lee, M.G. Giacomelli, Z. Wang, J.G. Fujimoto, and H. Mashimo,
“Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up
with optical coherence tomography angiography: A pilot study,” World Journal of
Gastroenterology, 25, 1997 (2019).
Z. Wang, H.-C. Lee, O.O. Ahsen, K. Liang, M. Figueiredo, Q. Huang, J.G. Fujimoto, and H.
Mashimo, “Computer-Aided Analysis of Gland-Like Subsurface Hyposcattering Structures in
Barrett's Esophagus using Optical Coherence Tomography,” Appl. Sci., 8, 2420 (2018).
W.-J Chen, Y.-Y. Chang, S.-C. Shen, Y.-L. Tzeng, H.-C. Lee, C.-H. Yang and M.-T. Tsai, “In vivo
detection of UV-induced acute skin effects using optical coherence tomography,” Biomed. Opt.
Express, 9, 4235-4245 (2018).
K. Liang, Z. Wang, O. O. Ahsen, H. C. Lee, B. Potsaid, V. Jayaraman, A. Cable, H. Mashimo, X.
Li, and J. G. Fujimoto, “Cycloid scanning for wide field optical coherence tomography
endomicroscopy and angiography in vivo,” Optica, 5, 36-43 (2018).
O. O. Ahsen, H.-C. Lee, K. Liang, Z. Wang, M. Figueiredo, Q. Huang, B. Potsaid, V. Jayaraman, J.
G. Fujimoto, and H. Mashimo, “Ultrahigh-speed endoscopic optical coherence tomography and
angiography enables delineation of lateral margins of endoscopic mucosal resection: a case
report,” Therap. Adv. Gastroenterol., 10, 931-936 (2017).
K. Liang, O. O. Ahsen, Z. Wang, H. C. Lee, W. Liang, B. Potsaid, T.-H. Tsai, M. G. Giacomelli,
V. Jayaraman, H. Mashimo, X. Li, and J. G. Fujimoto, “Endoscopic forward-viewing optical
coherence tomography and angiography with MHz swept source,” Opt. Lett 42, 3193-3196 (2017).
H.-C. Lee, O. O. Ahsen, J. J. Liu, T.-H. Tsai, Q. Huang, H. Mashimo and J. G. Fujimoto,
“Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence
tomography,” J. Biomed Opt., 22, 076001 (2017).
H.-C. Lee, O. O. Ahsen, K. Liang, Z. Wang, M. Figueiredo, M. G. Giacomelli, B. Potsaid, Q.
Huang, H. Mashimo, and J. G. Fujimoto, “Endoscopic optical coherence tomography angiography
microvascular features associated with dysplasia in Barrett's esophagus (with video),”
Gastrointest. Endosc., 86, 476-484 (2017).
S. Wan, H. C. Lee, X. Huang, T. Xu, T. Xu, X. Zeng, Z. Zhang, Y. Sheikine, J. L. Connolly, J. G.
Fujimoto, and C. Zhou, “Integrated local binary pattern texture features for classification of
breast tissue imaged by optical coherence microscopy”, Med. Image Anal., 38, 104-116 (2017).
Z. Wang, B. Potsaid, L. Chen, C. Doerr, H. C. Lee, T. Nielsen, V. Jayaraman, A. Cable, E.
Swanson, and J. G. Fujimoto, “Cubic meter volume optical coherence tomography,” Optica, 3,
1496-1503 (2016).
K. Liang, O. O. Ahsen, H. C. Lee, Z. Wang, B. Potsaid, M. Figueiredo, V. Jayaraman, A. Cable, Q.
Huang, H. Mashimo, and J. G. Fujimoto, “Volumetric Mapping of Barrett's Esophagus and Dysplasia
With en face Optical Coherence Tomography Tethered Capsule,” Am. J. Gastroenterol, 111,
1664-1666 (2016).
H. C. Lee, O. O. Ahsen, K. Liang, Z. Wang, C. Cleveland, L. Booth, B. Potsaid, V. Jayaraman, A.
E. Cable, H. Mashimo, R. Langer, G. Traverso, and J. G. Fujimoto, “Circumferential optical
coherence tomography angiography imaging of the swine esophagus using a micromotor balloon
catheter,” Biomed. Opt. Express, 7, 2927-2942 (2016).
Z. Wang*, H. C. Lee*, D. Vermeulen, L. Chen, T. Nielsen, S. Y. Park, A. Ghaemi, E. Swanson, and
J. G. Fujimoto, “Silicon Photonic Integrated Circuit Swept-Source Optical Coherence Tomography
Receiver with Dual Polarization, Dual Balanced, In-phase and Quadrature Detection,” Biomed. Opt.
Express 6, 2562-2574 (2015). (*equal contribution)
K. Liang, G. Traverso, H. C. Lee, O. O. Ahsen, Z. Wang, B. Potsaid, M. G. Giacomelli, V.
Jayaraman, R. Barman, A. Cable, H. Mashimo, R. Langer, and J. G. Fujimoto, “Ultrahigh speed en
face OCT capsule for endoscopic imaging,” Biomed. Opt. Express 6, 1146-1163 (2015).
O. O. Ahsen, H. C. Lee, M. G. Giacomelli, Z. Wang, K. Liang, T. H. Tsai, B. Potsaid, H. Mashimo,
J. G. Fujimoto, “Correction of rotation distortion for catheter-based en face OCT and OCT
angiography,” Opt. Lett 39, 5973-5976 (2014).
T. H. Tsai, H. C. Lee, O. O. Ahsen, K. Liang, M. G. Giacomelli, B. Potsaid, Y. K. Tao, V.
Jayaraman, M. Figueiredo, Q. Huang, H. Mashimo, A. Cable, and J. G. Fujimoto, “Ultrahigh speed
endoscopic optical coherence tomography for gastroenterology,” Biomed. Opt. Express 5, 4387-4404
(2014).
T. H. Tsai, O. O. Ahsen, H. C. Lee, K. Liang, M. Figueiredo, Y. K. Tao, M. G. Giacomelli, B.
Potsaid, V. Jayaraman, Q. Huang, A. Cable, J. G. Fujimoto, and H. Mashimo, “Endoscopic Optical
Coherence Angiography Enables Three Dimensional Visualization of Subsurface Microvasculature,”
Gastroenterology, 147, 1219-1221 (2014).
Z. Wang, H. C. Lee, O. O. Ahsen, B. Lee, W. Choi, B. Potsaid, J. J. Liu, V. Jayaraman, A. Cable,
M. F. Kraus, K. Liang, J. Hornegger, and J. G. Fujimoto, “Depth-encoded all fiber swept source
polarization sensitive OCT,” Biomed. Opt. Express 5, 2931-2949 (2014).
N. Zhang, T. H. Tsai, O. O. Ahsen, K. Liang, H. C. Lee, P. Xue, X. Li, and J. G. Fujimoto,
"Compact piezoelectric transducer fiber scanning probe for optical coherence tomography," Opt.
Lett 39, 186-188 (2014).
H.-C. Lee, J. J. Liu, Y. Sheikine, A. D. Aguirre, J. L. Connolly, and J. G. Fujimoto,
"Ultrahigh-speed spectral domain optical coherence microscopy," Biomed. Opt. Express 4,
1236-1254 (2013).
C. Zhou, T. H. Tsai, H. C. Lee, T. Kirtane, M. Figueiredo, Y. K. Tao, O. O. Ahsen, D. C. Adler,
J. M. Schmitt, Q. Huang, J. G. Fujimoto, and H. Mashimo, "Characterization of buried glands
before and after radiofrequency ablation by using 3-dimensional optical coherence tomography
(with videos)," Gastrointest Endosc 76, 32-40 (2012).
C. Zhou, T. Kirtane, T. H. Tsai, H. C. Lee, D. C. Adler, J. M. Schmitt, Q. Huang, J. G.
Fujimoto, and H. Mashimo, "Cervical inlet patch-optical coherence tomography imaging and
clinical significance," World J Gastroenterol 18, 2502-2510 (2012).
C. Zhou, T. Kirtane, T. H. Tsai, H. C. Lee, D. C. Adler, J. Schmitt, Q. Huang, J. G. Fujimoto,
and H. Mashimo, "Three-dimensional endoscopic optical coherence tomography imaging of cervical
inlet patch," Gastrointest Endosc 75, 675-677 (2012).
T. H. Tsai, C. Zhou, Y. K. Tao, H. C. Lee, O. O. Ahsen, M. Figueiredo, T. Kirtane, D. C. Adler,
J. M. Schmitt, Q. Huang, J. G. Fujimoto, and H. Mashimo, "Structural markers observed with
endoscopic 3-dimensional optical coherence tomography correlating with Barrett's esophagus
radiofrequency ablation treatment response (with videos)," Gastrointest Endosc 76, 1104-1112
(2012).
T. H. Tsai, C. Zhou, H. C. Lee, Y. K. Tao, O. O. Ahsen, M. Figueiredo, D. C. Adler, J. M.
Schmitt, Q. Huang, J. G. Fujimoto, and H. Mashimo, "Comparison of Tissue Architectural Changes
between Radiofrequency Ablation and Cryospray Ablation in Barrett's Esophagus Using Endoscopic
Three-Dimensional Optical Coherence Tomography," Gastroenterol Res Pract, 684832 (2012).
H. C. Lee, C. Zhou, D. W. Cohen, A. E. Mondelblatt, Y. Wang, A. D. Aguirre, D. Shen, Y.
Sheikine, J. G. Fujimoto, and J. L. Connolly, "Integrated optical coherence tomography and
optical coherence microscopy imaging of ex vivo human renal tissues," J Urol 187, 691-699
(2012).
A. Li, C. Zhou, J. Moore, P. Zhang, T.-H. Tsai, H.-C. Lee, D.M. Romano, M.L. McKee, D.A.
Schoenfeld, M.J. Serra, K. Raygor, H.F. Cantiello, J.G. Fujimoto, and R.E. Tanzi, “Changes in
the Expression of the Alzheimer’s Disease-Associated Presenilin Gene in Drosophila Heart Leads
to Cardiac Dysfunction,” Curr. Alzheimer Res., 8, 313-322 (2011).
C. Zhou, D.W. Cohen, Y. Wang, H.-C. Lee, A.E. Mondelblatt, T.-H. Tsai, A.D. Aguirre, J.G.
Fujimoto, and J.L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo
multiscale evaluation of human breast tissues,” Cancer Res. 70, 10071-10079 (2010).
C. Zhou, T.-H. Tsai, D.C. Adler, H.-C. Lee, D. Cohen, A. Mondelblatt, Y. Wang, J.L. Connolly,
and J.G. Fujimoto, “Photothermal optical coherence tomography in ex vivo human breast tissue
using gold nanoshells,” Opt. Lett 35, 700-702 (2010).
D.C. Adler, C. Zhou, T.-H. Tsai, H.-C. Lee, L. Becker, J.M. Schmitt, Q. Huang, J.G. Fujimoto,
and H. Mashimo, “Three-dimensional optical coherence tomography of Barrett’s esophagus and
buried glands beneath neosquamous epithelium following radiofrequency ablation,” Endoscopy 41,
773-776 (2009).
C.-K. Lee, M.-T. Tsai, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang,
“Diagnosis of oral submucous fibrosis with optical coherence tomography,” J. Biomedical Optics
14, 054008 (2009).
M.-T. Tsai, C.-K. Lee, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang,
“Differentiating oral lesions in different carcinogenesis stages with optical coherence
tomography,” J. Biomedical Optics 14, 044028 (2009).
M.-T. Tsai, H.-C. Lee, C.-K. Lee, C.-H. Yu, H.-M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang,
and C. C. Yang, "Effective indicators for diagnosis of oral cancer using optical coherence
tomography," Opt. Express 16, 15847-15862 (2008).
M.-T. Tsai, H.-C. Lee, C.-W. Lu, Y.-M. Wang, C.-K. Lee, C. C. Yang, and C.-P. Chiang,
“Delineation with an Oral Cancer Lesion with Swept-source Optical Coherence Tomography,” J.
Biomedical Optics 13, 044012 (2008).
C.-K. Lee, C.-W. Sun, P.-L. Lee, H.-C. Lee, C. C. Yang, C.-P. Jiang, Y.-P. Tong, T.-C. Yeh, and
J.-C. Hsieh, “Study of photon migration with various source-detector separations in
near-infrared spectroscopic brain imaging based on three-dimensional Monte Carlo modeling,”
Optics Express 13, 8339-8348 (2005).
Refereed Conference Presentations
Y.-S. Cheng, P.-C. Sung, Z.-W. Kao, F.-Y. Hua, T.-H. Chen, C.-B. Chueh, Y.-L. Wang, and H.-C.
Lee*, “Development of multi-view optical coherence tomography (OCT) with a registration
algorithm combining refractive index correction for tooth imaging,” European Conferences on
Biomedical Optics (ECBO), M1C.5, Munich, German, June, 2025.
C.-H. Peng, K.-L. Huang, J.-Z. Wang, H.-H. Chung, J.-T. Hsieh, and H.-C. Lee*, “High-speed,
long-range SS-OCT imaging based on HCG-VCSEL and real-time calibration framework,” European
Conferences on Biomedical Optics (ECBO), W5D.3, Munich, German, June, 2025.
Y.-S. Cheng, P.-C. Sung, Z.-W. Kao, F.-Y. Hua, T.-H. Chen, C.-B. Chueh, Y.-L. Wang, and H.-C.
Lee*, “Development of refractive index correction based image registration with multi-view
optical coherence tomography (OCT) for tooth imaging,” Advanced Lasers and Photon Sources
Conference (ALPS), OPIC, ALPS-H2-05, Yokohama, Japan, Apr. 2025.
C.-H. Peng, J.-Z. Wang, K.-L. Huang, H.-H. Chung, J.-T. Hsieh, and H.-C. Lee*, “Long-range
swept-source OCT imaging with real-time calibration using HCG-VCSEL laser,” Advanced Lasers and
Photon Sources Conference (ALPS), OPIC, ALPS-H2-04, Yokohama, Japan, Apr. 2025.
H.-C. Lee*, “Long-range imaging using swept-source OCT based on HCG-VCSEL,” Advanced Lasers and
Photon Sources Conference (ALPS), OPIC, ALPS4-01 (Invited), Yokohama, Japan, April, 2024.
P.-C. Sung, Z.-W. Kao, F.-Y. Hua, T.-H. Chen, H.-Y. Li, C.-B. Chueh, Y.-L. Wang, and H.-C. Lee*,
“Development of a multi-view OCT system based depth-encoded multiplexing,” Advanced Lasers and
Photon Sources Conference (ALPS), OPIC, ALPS4-02, Yokohama, Japan, April, 2024.
Z.-W. Kao, P.-C. Sung, F.-Y. Hua, C.-B. Chueh, H.-Y. Li, T.-H. Chen, Y.-L. Wang, and H.-C. Lee*,
“Development of Multi-view Optical Coherence Tomography (OCT)and Image Registration Algorithm
for Tooth Imaging,” Biomedical Imaging and Sensing Conference (BISC), SPIE, BISC7-01, Yokohama,
Japan, April, 2024.
C.-H. Peng, J.-Z. Wang, K.-L. Huang, T.-H. Chen, J.-T. Hsieh, and H.-C. Lee*, “Full-eye imaging
using swept-source OCT based on HCG-VCSEL,” Biomedical Imaging and Sensing Conference (BISC),
SPIE, BISC7-02, Yokohama, Japan, April, 2024.
P.-C. Huang, Y.-N. Tsai, Y.-S. Cheng, Y.-C. Lin, Y. Yasuno, and H.-C. Lee*, “Dynamic imaging of
the lung carcinoma (CA) cell spheroid with optical coherence microscopy (OCM) technology,”
Biomedical Imaging and Sensing Conference (BISC), SPIE, BISC7-03, Yokohama, Japan, April, 2024.
C.-B. Chueh, Z.-C. Liu, T.-H. Chen, Y.-Y. Li, M.-C, Tu, S.-J. Cheng, C.-K. Lee, S. See, and
H.-C. Lee*, “Using generative adversarial network and multi-scale optical coherence tomography
to reconstruct high-resolution volumetric images,” Photonics Europe, 13011-26, Strasbourg,
France, April, 2024.
M.-S. Wu, C.-B. Chueh, T.-A. Wang, T.-H. Chen, T.-Y. Tsai, B. E. Bouma, M. Villiger, and H.-C.
Lee*, “Multifunctional catheter-based optical coherence tomography system for oral cavity and
endocervical canal imaging (Invited Paper),” European Conferences on Biomedical Optics (ECBO),
12632-7, Munich, German, June, 2023.
T.-H. Chang, F.-Y. Hua, H.-Y. Li, Y.-L. Wang, Y.-R. Chou, and H.-C. Lee*, “Using a multi-angle
optical coherence tomography (OCT) system for the suppression of artifacts in the dental OCT
images,” European Conferences on Biomedical Optics (ECBO), 12632-20, Munich, German, June, 2023.
C.-B. Chueh, T.-H. Chen, Y.-Y. Li, M.-C. Tu, S.-J. Cheng, C.-K. Lee, S. See, H.-C. Lee*,
“Synthetic high-resolution, volumetric and wide field-of-view optical coherence tomography
images with generative adversarial networks,” European Conferences on Biomedical Optics (ECBO),
12632-65, Munich, German, June, 2023.
Y.-C. Wu, H.-F. Chen, T.-H. Chen, T.-Y. Tsai, C.-B. Chueh, J.-C. Tsai, and H.-C. Lee*,
“Comparison of scanning stability analysis with the dual-axis MEMS scanner based on switchable
driving mode in optical coherence tomography imaging technology,” Biomedical Imaging and Sensing
Conference (BISC), SPIE, BISC2-02, Yokohama, Japan, April, 2023.
C.-H. Peng, Y.-C. Mei, H.-K. Chen, T.-Y. Tsai, T.-H. Chen, C.-B. Chueh, D. Ellafi, C. Chase,
H.-C. Kuo, M. C. Y. Huang, and H.-C. Lee*, “Polarization-sensitive imaging using optical
coherence tomography and a HCG-VCSEL laser,” OPTO, Photonics West, 12439-22, San Francisco, USA,
Feb, 2023.
T.-H. Chen, Y.-H. Lee, C. Y. Ng, M.-T. Tsai, C.-K. Lee, and H.-C. Lee*, “Development of an
automatic algorithm enabling layer segmentation and optical characteristic analysis in skin
optical coherence tomography imaging”, BiOS, Photonics West, 12352-14, San Francisco, USA, Jan,
2023.
T.-Y. Tsai, T.-H. Chen, H.-K. Chen, C.-B. Chueh, D. Ellafi, C. Chase, H.-C. Kuo, M.-T. Tsai, M.
C. Y. Huang, and H.-C. Lee*, “High-speed optical coherence tomography imaging with a tunable
HCG-VCSEL light source at the 1060 nm wavelength window,” OPTO, Photonics West, 12020-18, San
Francisco, USA, Jan, 2022.
T.-H. Chen, Y.-C. Wu, C.-C. Li, M.-A. Chen, T.-Y. Tsai, C.-B. Chueh, M.-T. Tsai, Y. Yasuno,
M.-K. Pan, and H.-C. Lee*, “Identification of Changes in the Microvasculature in Mouse Brain
Among Different Physiological States Using Optical Coherence Tomography Angiography,” European
Conferences on Biomedical Optics (ECBO), OSA, Virtual Meeting, June, 2021.
H.-C. Lee*, T.-H. Chen, Y.-C. Wu, C.-C. Li, Y.-W. Chang, M.-A. Chen, T.-Y. Tsai, C.-B. Chueh,
M.-T. Tsai, Y. Yasuno, and M.-K. Pan, “A pilot study of developing a small footprint imaging
platform with optical coherence tomography (OCT) and OCT angiography for mouse brain imaging in
vivo,” Biomedical Imaging and Sensing Conference (BISC), SPIE, BISC Satellite in Taiwan-06,
April, 2021.
T.-Y. Tsai, C.-B. Chueh, T.-H. Chen, M.-S. Wu, M.-T. Tsai, and H.-C. Lee*, “High-speed and
wide-field endoscopic optical coherence tomography imaging of the oral mucosa with a micromotor
imaging catheter and polarization diversity detection,” Biomedical Imaging and Sensing
Conference (BISC), SPIE, BISC-P-08, Yokohama, Japan (virtual meeting in parallel), April, 2021.
Y.-L. Chen, T.-H. Chen, T.-Y. Tsai, C.-B. Chueh, Y.-C. Wu, M.-T. Tsai, C.-K. Lee, and H.-C.
Lee*, “Graphics processing unit (GPU) accelerated microvascular imaging framework with optical
coherence tomography (OCT) and OCT angiography techniques,” Biomedical Imaging and Sensing
Conference (BISC), SPIE, BISC-P-09, Yokohama, Japan (virtual meeting in parallel), April, 2021.
Z.-J. Wu, T.-Y. Tsai, M.-S. Wu, C.-W. Chen, and H.-C. Lee*, “Development of a miniature imaging
head combing wide-angle camera and optical coherence tomography for the semiautonomous
laparoscope surgery procedure,” Biomedical Imaging and Sensing Conference (BISC), SPIE,
BISC-P-15, Yokohama, Japan (virtual meeting in parallel), April, 2021.
T.-C. Chang, T.-H. Chen, T.-Y. Tsai, C.-B. Chueh, Y.-P. Huang, M.-T. Tsai, C.-K. Lee, and H.-C.
Lee*, “Real time functional optical coherence tomography imaging,” Biomedical Imaging and
Sensing Conference (BISC), SPIE, BISC-7-01(invited), Yokohama, Japan, April, 2020.
M.-S. Wu, Y.-C. Wu, C.-Y. Wang, T.-Y. Tsai, T.-H. Chen, Y.-N. Tsai, M.-T. Tsai, C.-C. Wang and
H.-C. Lee*, “Development of a catheter-based optical coherence tomography system for the early
detection of cervical precancerous lesions,” Biomedical Imaging and Sensing Conference (BISC),
SPIE, BISC-2-03, Yokohama, Japan, April, 2020.
C.-Y. Wang, C.-B. Chueh, T.-Y. Tsai, J.-C. Lee, T.-C. Chang, T.-H. Chen, Y.-P. Hung, M.-K. Pang
and H.-C. Lee*, “Investigation of tissue architectures with a long-wavelength and multiscale
optical coherence tomography imaging system,” Biomedical Imaging and Sensing Conference (BISC),
BISC-2-04, Yokohama, Japan, April, 2020.
Y.-C. Wu, T.-H. Chen, T.-Y. Tsai, T.-C. Chang, C.-B. Chueh, C.-Y. Wang, Y.-P. Huang, M.-T. Tsai,
and H.-C. Lee*, “Comparison of vascular image quality with different sweep rate laser light
source based on variable interscan time analysis in optical coherence tomography angiography
skin imaging,” Biomedical Imaging and Sensing Conference (BISC), SPIE, BISC-7-04, Yokohama,
Japan, April, 2020.
T.-Y. Tsai, T.-H. Chen, H.-C. Chen, H. Wang, Y.-P. Huang, T.-C. Chang, Y.-W Chang, Y.-P. Hung,
M.-T. Tsai, C.-H. Wang, and H.-C. Lee*, “Quantitative spectroscopic comparison of the optical
properties of the mouse cochlear microstructures using optical coherence tomography at 1.3 µm
and 1 µm wavelength regimes,” BiOS, Photoniscs West, 11213-5, San Francisco, USA, Feb, 2020.
C.-B. Chueh, C.-Y. Wang, T.-Y. Tsai, Y.-P. Huang, T.-C. Chang, T.-H. Chen, Y.-N. Tsai, Y.-P.
Hung and H.-C. Lee*, “Multiscale imaging of the ex vivo oral precancerous lesions with a custom
developed swept-source optical coherence tomography/microscopy platform and a 1.7 μm
wavelength-swept laser,” BiOS, Photonics West, 11217-12, San Francisco, USA, Feb, 2020.
T.-H. Chen, T.-Y. Tsai, Y.-P. Huang, C.-B. Chueh, M.-S. Wu, Y.-C Wu, Y.-P. Hung, M.-T. Tsai and
H.-C. Lee*, “Quantitative analysis of the microvasculature flow speed using optical coherence
tomography angiography technique and variable interscan time algorithm,” BiOS, Photonics West,
11251-88, San Francisco, USA, Feb, 2020.
Y.-N. Tsai, Y.-W. Chang, C.-C. Ni, T.-H. Chen, T.-Y. Tsai, Y.-P. Huang, C.-C. Yang and H.-C.
Lee*, “Development of a time lapse tumor cell spheroid imaging system with a high-resolution
spectral-domain optical coherence microscopy system,” BiOS, Photonics West, 11243-13, San
Francisco, USA, Feb, 2020.
H.-C. Lee*, “Recent advances in the development and applications of endoscopic optical coherence
tomography,” The 4th International Conference on Biophotonics, T4.1, Taipei, Taiwan, Sep. 2019.
Y.-P. Huang, T.-Y. Tsai, T.-H. Chen, C.-B. Chueh, Y.-P. Hung and H.-C. Lee*, “The single
software architecture supporting Fourier domain optical coherence tomography system,” The 4th
International Conference on Biophotonics, T4.2, Taipei, Taiwan, Sep. 2019.
T.-H. Chen, T.-Y. Tsai, H.-C. Chen, C.-B. Chueh, B.-H. Huang, Y.-N. Tsai, M.-T. Tsai, C.-H. Wang
and H.-C. Lee*, “Swept-Source Optical Coherence Tomography Imaging of the Guinea Pig Cochlea,”
Biomedical Imaging and Sensing Conference (BISC), SPIE, BISC-2-03, Yokohama, Japan, April, 2019.
C.-B. Chueh, T.-Y. Tsai, Y.-P. Huang, T.-H. Chen, Y.-N. Tsai, C.-Y. Wang, T.-C. Chang, Y.-P.
Hung and H.-C. Lee*, “Development of a Long-Wavelength Swept-Source Optical Coherence Tomography
System for High-Content Ex Vivo Tissue Imaging,” Biomedical Imaging and Sensing Conference
(BISC), SPIE, BISC-P-04, Yokohama, Japan, April, 2019.
T.-Y. Tsai, Y.-P. Huang, T.-H. Chen, C.-B. Chueh, H.-Y. Peng, M.-S. Wu, Y.-C. Wu, Y.-P. Hung,
M.-T. Tsai and H.-C. Lee*, “Differentiation of the microvasculature with different blood flow
speed based on variable interscan time analysis in OCT angiography skin imaging,” Biomedical
Imaging and Sensing Conference (BISC), SPIE, BISC-P-17, Yokohama, Japan, April, 2019.
M.-T. Tsai, Y.-L. Wang, C.-Y. Ke, H.-C. Lee, and Y.-J. Lee, “Early diagnosis of teeth caries
with non-invasive optical coherence tomography,” Biomedical Imaging and Sensing Conference
(BISC), SPIE, BISC-P-25, Yokohama, Japan, April, 2019.
Y.-N. Tsai, Y.-P. Huang, T.-H. Chen, C.-B. Chueh, T.-Y. Tsai, C.-C. Hsieh, X.-Y. Luo, Y.-P.
Hung, C.-C. Yang and H.-C. Lee*, “Investigation of the architectural changes of the tumor cell
spheroid with the interaction of gold nanoparticles using a high-resolution inverted optical
coherence microscopy system,” BiOS, Photonics West, 10876-41, San Francisco, USA, Feb, 2019.
H.-C. Lee*, K. Liang, O.O. Ahsen, Z. Wang, M. Figueiredo, B.M. Potsaid, V. Jayaraman, Q. Huang,
H. Mashimo, J.G. Fujimoto, “(Invited) Endoscopic optical coherence tomography and angiography
for gastroenterology applications,” Biomedical Imaging and Sensing Conference (BISC), SPIE,
10711-6, Yokohama, Japan, April, 2018.
H.-C. Lee, and M.-T. Tsai, “Texture analysis of optical coherence tomography images obtained
during tumor development,” OSJ-OSA-OSK Joint Symposia on Optics (Optics and Photonics Japan
2018), 31Ppj2, Tokyo, Japan, November, 2018.
H.-C. Lee, O. Fass, O.O. Ahsen, K. Liang, Z. Wang, M. Figueiredo, B. Potsaid, V. Jayaraman, Q.
Huang, J.G. Fujimoto, H. Mashimo, "Endoscopic Optical Coherence Tomography Microangiography
Identifies the Altered Microvasculature of the Terminal Ileum in Crohn’s Disease," Digestive
Disease Week, Chicago, IL, USA, May, 2017.
H.-C. Lee, O.O. Ahsen, K. Liang, Z. Wang, M. Figueiredo, B. Potsaid, V. Jayaraman, Q. Huang, H.
Mashimo, J.G. Fujimoto, "Novel Ultrahigh Speed Endoscopic OCT Angiography Identifies Both
Architectural and Microvascular Changes in Patients With Gastric Antral Vascular Ectasia (GAVE)
Undergoing Radiofrequency Ablation (RFA) Treatment," Digestive Disease Week, San Diego, CA, USA,
May, 2016.
H.-C. Lee, O.O. Ahsen, K. Liang, Z. Wang, M.G. Giacomelli, M. Figueiredo, Q. Huang, B. Potsaid,
V. Jayaraman, H. Mashimo, J.G. Fujimoto, "Ultrahigh Speed Endoscopic Optical Coherence
Tomography Angiography for Visualization of Subsurface Vasculature in Barrett's Esophagus and
Dysplasia," Digestive Disease Week, Washington, D.C., USA, May, 2015.
H.-C. Lee, K. Liang, O.O. Ahsen, M.G. Giacomelli, Z. Wang, M. Figueiredo, Q. Wang, B. Potsaid,
V. Jayaraman, J.G. Fujimoto, H. Mashimo, "Ultrahigh Speed Endoscopic Optical Coherence
Tomography and Angiography for Investigating Terminal Ileum With Chronic Inflammation,"
Digestive Disease Week, Washington, D.C., USA, May, 2015.
H.-C. Lee, O. O. Ahsen, K. Liang, M. G. Giacomelli, Z. Wang, B. Potsaid, V. Jayaraman, M.
Figueiredo, Q. Huang, A. E. Cable, H. Mashimo, and J. G. Fujimoto, “Ultrahigh speed endoscopic
structural and angiographic OCT imaging,” BiOS, Photonics West, San Francisco, USA, Feb, 2015.
H.-C. Lee, O. O. Ahsen, T.-H. Tsai, M. G. Giacomelli, Z. Wang, K. Liang, M. Figueiredo, Q.
Huang, B. Potsaid, J. G. Fujimoto, and H. Mashimo, “Novel Ultrahigh Speed Optical Coherence
Tomography and Micromotor Imaging Probe for Investigating Microvasculature in the
Gastrointestinal Tract,” Digestive Disease Week, Chicago, USA, May, 2014.
H.-C. Lee, J. J. Liu, T.-H. Tsai, B. Potsaid, M. Kraus, M. Giacomelli, Y. K. Tao, J. G.
Fujimoto, and H. Mashimo, “Imaging the Dynamics of Radiofrequency Ablation using Ultrahigh-Speed
Three-Dimensional Optical Coherence Tomography,” Digestive Disease Week, Orlando, USA, May,
2013.
H.-C. Lee, C. Zhou, T.-H. Tsai, T. Kirtane, Y. K. Tao, O. O. Ahsen, D. C. Adler, J. M. Schmitt,
Q. Huang, J. G. Fujimoto, and H. Mashimo, “Three-dimensional Optical Coherence Tomography on
Endoscopic Mucosal Resection Specimens Confirms Identification of Malignant from Metaplastic
Lesions in Patients with Barrett’s Esophagus,” Digestive Disease Week, Chicago, USA, May, 2011.
H.-C. Lee, C. Zhou, Y. Wang, A. D. Aquirre, T.-H. Tsai, D. W. Cohen, J. L. Connolly, and J. G.
Fujimoto, “Integrated Optical Coherence Tomography and Optical Coherence Microscopy Imaging of
Human Pathology,” BiOS, Photonics West, San Francisco, USA, Jan. 2010.
H.-C. Lee, M.-T. Tsai, C.-K. Lee, C.-H. Yu, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C.
Yang, “Tracking the Regression of Oral Cancer after Photodynamic Therapy with Optical Coherence
Tomography,” BiOS, Photonics West, San Jose, USA, Jan. 2009.
H.-C. Lee, C.-K. Lee, Y.-W. Kiang, C. C. Yang, C.-W. Sun, and Y.-P. Tong, “Monte Carlo
Simulations on Transmitted Signals through Biological Tissues with Aperture, Angle, Time, and
Polarization Gating,” BiOS, Photonics West, San Jose, USA, Jan. 2005.
Members
Doctoral Students
Name
Research topics
You-Nan Tsai (A-Nan)
dynamic OCT imaging of the spheroid.
spectrometer design and implementation.
Chuan-Bor Chueh (Chamber)
high-speed and functional OCT imaging.
computation engine.
graphic user interface.
(AI-)imaging processing and registration.
Tai-Ang Wang (Sun)
high speed and function OCT imaging.
line-field OCT.
multimodal OCT platform.
Chien-Hua Peng (Justin)
Ophthalmologic OCT imaging.
computation engine.
high speed and function OCT imaging.
Yin-Shen Cheng (Ken)
line-field OCT.
multimodal OCT platform.
Pei-Chin Huang (Peggy)
dynamic OCT imaging of the spheroid.
Cheng-Hsi Yang (Alex)
AI-imaging processing.
edge computing.
Master Students
Name
Research topics
Hao-Hsun Chung (Alston)
multimodal OCT platform for industrial application
Hao-Syuan Chen (Sean)
FPGA OCT
Ting-Ya Wu (Claire)
dental OCT
Xin-Yu Hou (Isa)
Ophthalmologic OCT imaging / handheld OCT
Wei-Chung Cheng (Irene)
AI-imaging processing
Po-Hsien Yu (Sam)
dynamic OCT imaging of the spheroid / computation engine
Chieh Shen (Jacky)
line-field OCT
Chih-Hsuan Hu (Nelson)
FPGA OCT
Yu-Hsuan Chien (Ava)
multimodal OCT platform for industrial application
